Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine

• Main Authors: Yusuke Kamiya (Author), Tsutomu Yamaki (Author), Shigehiro Omori (Author), Masaki Uchida (Author), Kazuo Ohtake (Author), Mitsutoshi Kimura (Author), Hiroshi Yamazaki (Author), Hideshi Natsume (Author)
• Format: Book
• Published: MDPI AG, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We reported that the introduction of polyethylene glycol (PEG) to poly-l-ornithine (PLO), which is an homopolymeric basic amino acid having absorption-enhancement ability, prolonged retention time in an in vitro inclined plate test, probably due to an increase in viscosity caused by PEGylation. The...