Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation

• Main Authors: Angelica Giuliani (Author), Anna Maria Giudetti (Author), Daniele Vergara (Author), Laura Del Coco (Author), Deborah Ramini (Author), Sara Caccese (Author), Matilde Sbriscia (Author), Laura Graciotti (Author), Gianluca Fulgenzi (Author), Luca Tiano (Author), Francesco Paolo Fanizzi (Author), Fabiola Olivieri (Author), Maria Rita Rippo (Author), Jacopo Sabbatinelli (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular impairments. Albeit in a state of permanent grow...