Relative Contributions of Solubility and Mobility to the Stability of Amorphous Solid Dispersions of Poorly Soluble Drugs: A Molecular Dynamics Simulation Study

• 主要な著者: Michael Brunsteiner (著者), Johannes Khinast (著者), Amrit Paudel (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2018-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Amorphous solid dispersions are considered a promising formulation strategy for the oral delivery of poorly soluble drugs. The limiting factor for the applicability of this approach is the physical (in)stability of the amorphous phase in solid samples. Minimizing the risk of reduced shelf life for a...