Elucidation of the Molecular Mechanism of Wet Granulation for Pharmaceutical Standard Formulations in a High-Speed Shear Mixer Using Near-Infrared Spectroscopy

• 主要な著者: Ryo Omata (著者), Yusuke Hattori (著者), Tetsuo Sasaki (著者), Tomoaki Sakamoto (著者), Makoto Otsuka (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The granulation process of pharmaceutical standard formulation in a high-speed shear wet granulation (HSWG) was measured by in-line near-infrared spectroscopy (NIRS) and agitation power consumption (APC) methods. The F-1, F-2, and F-3 formulations (500 g) contained 96% <i>w</i>/<i>...