Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro

• Main Authors: Francisca Espinoza (Author), Rocío Magdalena (Author), Natalia Saldivia (Author), Nery Jara (Author), Fernando Martínez (Author), Luciano Ferrada (Author), Katterine Salazar (Author), Felipe Ávila (Author), Francisco Nualart (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reduced form of vitamin C, ascorbic acid (AA), has been related with gene expression and cell differentiation in the cerebral cortex. In neurons, AA is mainly oxidized to dehydroascorbic acid (DHA); however, DHA cannot accumulate intracellularly because it induces metabolic changes and cell deat...