Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [18F]FAMT positron emission tomography

• Main Authors: Ling Wei (Author), Hideyuki Tominaga (Author), Ryuichi Ohgaki (Author), Pattama Wiriyasermkul (Author), Kohei Hagiwara (Author), Suguru Okuda (Author), Kyoichi Kaira (Author), Yukio Kato (Author), Noboru Oriuchi (Author), Shushi Nagamori (Author), Yoshikatsu Kanai (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A PET tracer for tumor imaging, 3-18F-l-α-methyl-tyrosine ([18F]FAMT), has advantages of high cancer-specificity and low physiological background. In clinical studies, FAMT-PET has been proved useful for the detection of malignant tumors and their differentiation from inflammation and benign lesions...