A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy

• Main Authors: Xinyu Hou (Author), Chenting Shou (Author), Muye He (Author), Jiajun Xu (Author), Yi Cheng (Author), Zeting Yuan (Author), Minbo Lan (Author), Yuzheng Zhao (Author), Yi Yang (Author), Xianjun Chen (Author), Feng Gao (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A light-switchable transgene system called LightOn gene expression system could regulate gene expression with a high on/off ratio under blue light, and have great potential for spatiotemporally controllable gene expression. We developed a nanoparticle drug delivery system (NDDS) to achieve tumor mic...