Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue

• Main Authors: Ricardo J. Samms (Author), GuoFang Zhang (Author), Wentao He (Author), Olga Ilkayeva (Author), Brian A. Droz (Author), Steven M. Bauer (Author), Cynthia Stutsman (Author), Valentina Pirro (Author), Kyla A. Collins (Author), Ellen C. Furber (Author), Tamer Coskun (Author), Kyle W. Sloop (Author), Joseph T. Brozinick (Author), Christopher B. Newgard (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Tirzepatide, a dual GIP and GLP-1 receptor agonist, delivered superior glycemic control and weight loss compared to selective GLP-1 receptor (GLP-1R) agonism in patients with type 2 diabetes (T2D). These results have fueled mechanistic studies focused on understanding how tirzepatide ach...