Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome
Objective: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS1 function in hypothalamic neurones, whereas dispr...
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Elsevier,
2024-06-01T00:00:00Z.
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