Mesenchymal-specific Alms1 knockout in mice recapitulates metabolic features of Alström syndrome

• Main Authors: Eleanor J. McKay (Author), Ineke Luijten (Author), Xiong Weng (Author), Pablo B. Martinez de Morentin (Author), Elvira De Frutos González (Author), Zhanguo Gao (Author), Mikhail G. Kolonin (Author), Lora K. Heisler (Author), Robert K. Semple (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS1 function in hypothalamic neurones, whereas dispr...