PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice

• Autores principales: Marie K. Holt (Autor), Daniel R. Cook (Autor), Daniel I. Brierley (Autor), James E. Richards (Autor), Frank Reimann (Autor), Alexander V. Gourine (Autor), Nephtali Marina (Autor), Stefan Trapp (Autor)
• Formato: Libro
• Publicado: Elsevier, 2020-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used as anti-diabetic drugs and are approved for obesity treatment. However, GLP-1RAs also affect heart rate (HR) and arterial blood pressure (ABP) in rodents and humans. Although the activation of GLP-1 receptors (GLP-1R) is known...