α-Mangostin Induces Ca2+-ATPase-Dependent Apoptosis via Mitochondrial Pathway in PC12 Cells

We investigated the cell death effects of eight xanthones on PC12 rat pheochromocytoma cells. Among these compounds, α-mangostin, from the fruit hull of Garcinia mangostana L., had the most potent effect with the EC50 value of 4 μM. α-Mangostin-treated PC12 cells demonstrated typical apoptotic DNA f...

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Main Authors: Ayumi Sato (Author), Hironori Fujiwara (Author), Hisae Oku (Author), Kyoko Ishiguro (Author), Yasushi Ohizumi (Author)
Format: Book
Published: Elsevier, 2004-01-01T00:00:00Z.
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3rd Floor Main Library

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