Novel degradation products of argatroban: Isolation, synthesis and extensive characterization using NMR and LC-PDA-MS/Q-TOF

• Principais autores: Vinodh Guvvala (Autor), Venkatesan Chidambaram Subramanian (Autor), Jaya Shree Anireddy (Autor), Mahesh Konda (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2018-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Forced degradation study of argatroban under conditions of hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress, as suggested in the ICH Q1A (R2), was accomplished. The drug showed significant degradation under hydrolysis (acidic, alkaline) and oxidation (peroxide stre...