Resistance to immune checkpoint inhibitors in colorectal cancer with deficient mismatch repair/microsatellite instability: misdiagnosis, pseudoprogression and/or tumor heterogeneity?

• Main Authors: Nicola Normanno (Author), Vincenza Caridi (Author), Matteo Fassan (Author), Antonio Avallone (Author), Fortunato Ciardiello (Author), Carmine Pinto (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal carcinoma (CRC) with deficiency of the deficient mismatch repair (dMMR) pathway/microsatellite instability (MSI) is characterized by a high mutation load and infiltration of immune cells in the tumor microenvironment. In agreement with these findings, clinical trials have demonstrated a s...