PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain

• Main Authors: Laferrière Andre (Author), Pitcher Mark H (Author), Haldane Anne (Author), Huang Yue (Author), Cornea Virginia (Author), Kumar Naresh (Author), Sacktor Todd C (Author), Cervero Fernando (Author), Coderre Terence J (Author)
• Format: Book
• Published: SAGE Publishing, 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Chronic pain occurs when normally protective acute pain becomes pathologically persistent. We examined here whether an isoform of protein kinase C (PKC), PKMζ, that underlies long-term memory storage in various brain regions, also su...