Rapid Weight Loss and Severe Failure to Thrive Mimicking Lipodystrophy Syndrome in a 1-Year-Old Taiwanese Girl with Costello Syndrome

• Main Authors: Yu-Min Syu (Author), Hung-Chang Lee (Author), Jui-Hsing Chang (Author), Chung-Lin Lee (Author), Chih-Kuang Chuang (Author), Huei-Ching Chiu (Author), Ya-Hui Chang (Author), Hsiang-Yu Lin (Author), Shuan-Pei Lin (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Costello syndrome (CS) is a type of RASopathy caused mainly by de-novo heterozygous pathogenic variants in the <i>HRAS</i> gene located on chromosome 11p15.5. The phenotype of CS is characterized by prenatal overgrowth, postnatal failure to thrive, curly or sparse fine hair, coarse facia...