Enhancement of apixaban's solubility and dissolution rate by inclusion complex (β-cyclodextrin and hydroxypropyl β-cyclo¬dextrin) and computational calculation of their inclusion complexes

Enhancement of apixaban's solubility and dissolution rate by inclusion complex (β-cyclodextrin and hydroxypropyl β-cyclo¬dextrin) and computational calculation of their inclusion complexes

Background and Purpose: Apixaban (AP) is a factor X inhibitor, an orally active drug that inhibits blood coagulation for better prevention of venous thromboembolism. It has poor solubility, dissolution rate and low bioavailability. The aim of this study was to improve the aqueous solubility and diss...

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Main Authors: Zainab N. Salman (Author), Israa Al-Ani (Author), Khaldun M. Al Azzam (Author), Bashar JM. Majeed (Author), Hassan H. Abdallah (Author), El-Sayed Negim (Author)
Format: Book
Published: International Association of Physical Chemists (IAPC), 2023-08-01T00:00:00Z.
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