The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer

• Main Authors: Dmitry Morozov (Author), Vladimir Mironov (Author), Roman V. Moryachkov (Author), Irina A. Shchugoreva (Author), Polina V. Artyushenko (Author), Galina S. Zamay (Author), Olga S. Kolovskaya (Author), Tatiana N. Zamay (Author), Alexey V. Krat (Author), Dmitry S. Molodenskiy (Author), Vladimir N. Zabluda (Author), Dmitry V. Veprintsev (Author), Alexey E. Sokolov (Author), Ruslan A. Zukov (Author), Maxim V. Berezovski (Author), Felix N. Tomilin (Author), Dmitri G. Fedorov (Author), Yuri Alexeev (Author), Anna S. Kichkailo (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimiza...