A Single-Run HPLC-MS Multiplex Assay for Therapeutic Drug Monitoring of Relevant First- and Second-Line Antibiotics in the Treatment of Drug-Resistant Tuberculosis

• Main Authors: Niklas Köhler (Author), Hande Karaköse (Author), Hans-Peter Grobbel (Author), Doris Hillemann (Author), Sönke Andres (Author), Christina König (Author), Barbara Kalsdorf (Author), Thomas Theo Brehm (Author), Laura Böttcher (Author), Inna Friesen (Author), Harald Hoffmann (Author), Dražen Strelec (Author), Dagmar Schaub (Author), Charles A. Peloquin (Author), Stefan Schmiedel (Author), Laurent A. Decosterd (Author), Eva Choong (Author), Sebastian G. Wicha (Author), Rob E. Aarnoutse (Author), Christoph Lange (Author), Patricia M. Sánchez Carballo (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The treatment of drug-resistant <i>Mycobacterium tuberculosis</i> relies on complex antibiotic therapy. Inadequate antibiotic exposure can lead to treatment failure, acquired drug resistance, and an increased risk of adverse events. Therapeutic drug monitoring (TDM) can be used to optimi...