Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

• Main Authors: Long-fei Mao (Author), Zhen-Zhen Wang (Author), Qiong Wu (Author), Xiaojie Chen (Author), Jian-Xue Yang (Author), Xin Wang (Author), Yue-Ming Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR, and HR MS. Preliminary antitumor activity assay r...