Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism

This study investigated the pharmacokinetics of tofacitinib in rats and the effects of first-pass metabolism on tofacitinib pharmacokinetics. Intravenous administration of 5, 10, 20, and 50 mg/kg tofacitinib showed that the dose-normalized area under the plasma concentration-time curve from time zer...

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Main Authors: Ji Sang Lee (Author), So Hee Kim (Author)
Format: Book
Published: MDPI AG, 2019-07-01T00:00:00Z.
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3rd Floor Main Library

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