Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism
This study investigated the pharmacokinetics of tofacitinib in rats and the effects of first-pass metabolism on tofacitinib pharmacokinetics. Intravenous administration of 5, 10, 20, and 50 mg/kg tofacitinib showed that the dose-normalized area under the plasma concentration-time curve from time zer...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
MDPI AG,
2019-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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