Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs

• Main Authors: Jennifer E. Hewitt (Author), Amelia K. Pollard (Author), Leila Lesanpezeshki (Author), Colleen S. Deane (Author), Christopher J. Gaffney (Author), Timothy Etheridge (Author), Nathaniel J. Szewczyk (Author), Siva A. Vanapalli (Author)
• Format: Book
• Published: The Company of Biologists, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Muscle strength is a key clinical parameter used to monitor the progression of human muscular dystrophies, including Duchenne and Becker muscular dystrophies. Although Caenorhabditis elegans is an established genetic model for studying the mechanisms and treatments of muscular dystrophies, analogous...