The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis

• Main Authors: David B. Melville (Author), Mercedes Montero-Balaguer (Author), Daniel S. Levic (Author), Kevin Bradley (Author), Jeffrey R. Smith (Author), Antonis K. Hatzopoulos (Author), Ela W. Knapik (Author)
• Format: Book
• Published: The Company of Biologists, 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Craniofacial and skeletal dysmorphologies account for the majority of birth defects. A number of the disease phenotypes have been attributed to abnormal synthesis, maintenance and composition of extracellular matrix (ECM), yet the molecular and cellular mechanisms causing these ECM defects r...