The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis

• Auteurs principaux: David B. Melville (Auteur), Mercedes Montero-Balaguer (Auteur), Daniel S. Levic (Auteur), Kevin Bradley (Auteur), Jeffrey R. Smith (Auteur), Antonis K. Hatzopoulos (Auteur), Ela W. Knapik (Auteur)
• Format: Livre
• Publié: The Company of Biologists, 2011-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

SUMMARY Craniofacial and skeletal dysmorphologies account for the majority of birth defects. A number of the disease phenotypes have been attributed to abnormal synthesis, maintenance and composition of extracellular matrix (ECM), yet the molecular and cellular mechanisms causing these ECM defects r...