Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo

• Main Authors: Yang Xing (Author), Xiong Yong-lao (Author), Wei Li-na (Author), Liang Xiao-yan (Author), Li Yi (Author), Shi Hui-gan (Author), Yang Zi-hong (Author)
• Format: Book
• Published: BMC, 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>17alpha-hydroxylase/17, 20-lyase encoded by CYP17 is the key enzyme in androgen biosynthesis pathway. Previous studies demonstrated the accentuation of the enzyme in patients with polycystic ovary syndrome (PCOS) was the most importa...