TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality

• Main Authors: Frederike Sass (Author), Christian Schlein (Author), Michelle Y. Jaeckstein (Author), Paul Pertzborn (Author), Michaela Schweizer (Author), Thorsten Schinke (Author), Andrea Ballabio (Author), Ludger Scheja (Author), Joerg Heeren (Author), Alexander W. Fischer (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Brown adipose tissue (BAT) thermogenesis offers the potential to improve metabolic health in mice and humans. However, humans predominantly live under thermoneutral conditions, leading to BAT whitening, a reduction in BAT mitochondrial content and metabolic activity. Recent studies have e...