Limited efficacy of repeated praziquantel treatment in Schistosoma mansoni infections as revealed by highly accurate diagnostics, PCR and UCP-LF CAA (RePST trial).

• Main Authors: Pytsje T Hoekstra (Author), Miriam Casacuberta-Partal (Author), Lisette van Lieshout (Author), Paul L A M Corstjens (Author), Roula Tsonaka (Author), Rufin K Assaré (Author), Kigbafori D Silué (Author), Eliézer K N'Goran (Author), Yves K N'Gbesso (Author), Eric A T Brienen (Author), Meta Roestenberg (Author), Stefanie Knopp (Author), Jürg Utzinger (Author), Jean T Coulibaly (Author), Govert J van Dam (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Most studies assessing praziquantel (PZQ) efficacy have used relatively insensitive diagnostic methods, thereby overestimating cure rate (CR) and intensity reduction rate (IRR). To determine accurately PZQ efficacy, we employed more sensitive DNA and circulating antige...