RREB1-mediated SUMOylation enhancement promotes chemoresistance partially by transcriptionally upregulating UBC9 in colorectal cancer

• Главные авторы: Ya-nan Deng (Автор), Ying Chen (Автор), Shan Gao (Автор), Nan Zhang (Автор), Yinheng Luo (Автор), Shu Luo (Автор), Qiu Li (Автор), Xianghui Fu (Автор), Shufang Liang (Автор)
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• Опубликовано: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Предметы: article
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Chemoresistance is a main cause of chemotherapy failure and tumor recurrence. The effects of global protein SUMOylation on chemoresistance in colorectal cancer (CRC) remains to be investigated. Herein, we have proposed that the elevated SUMO2/3-modified proteins confer 5-fluorouracil (5-FU) chemores...