RREB1-mediated SUMOylation enhancement promotes chemoresistance partially by transcriptionally upregulating UBC9 in colorectal cancer

• Main Authors: Ya-nan Deng (Author), Ying Chen (Author), Shan Gao (Author), Nan Zhang (Author), Yinheng Luo (Author), Shu Luo (Author), Qiu Li (Author), Xianghui Fu (Author), Shufang Liang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemoresistance is a main cause of chemotherapy failure and tumor recurrence. The effects of global protein SUMOylation on chemoresistance in colorectal cancer (CRC) remains to be investigated. Herein, we have proposed that the elevated SUMO2/3-modified proteins confer 5-fluorouracil (5-FU) chemores...