Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C₁₀)

• Main Authors: Caroline Twarog (Author), Sarinj Fattah (Author), Joanne Heade (Author), Sam Maher (Author), Elias Fattal (Author), David J. Brayden (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Salcaprozate sodium (SNAC) and sodium caprate (C₁₀) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied for over 30 years, yet there...