Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

• Main Authors: Chunfang Xie (Author), Julien Slagboom (Author), Laura-Oana Albulescu (Author), Govert W. Somsen (Author), Freek J. Vonk (Author), Nicholas R. Casewell (Author), Jeroen Kool (Author)
• Format: Book
• Published: Elsevier, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific phospholipase A2 inhibitor), marimastat (broad spec...