Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms
Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific phospholipase A2 inhibitor), marimastat (broad spec...
Saved in:
Main Authors: | Chunfang Xie (Author), Julien Slagboom (Author), Laura-Oana Albulescu (Author), Govert W. Somsen (Author), Freek J. Vonk (Author), Nicholas R. Casewell (Author), Jeroen Kool (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2020-10-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.
by: Julien Slagboom, et al.
Published: (2020) -
Development of a high-throughput in vitro screening method for the assessment of cell-damaging activities of snake venoms.
by: Matyas A Bittenbinder, et al.
Published: (2023) -
Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.
by: Nessrin Alomran, et al.
Published: (2021) -
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors
by: Rachel H. Clare, et al.
Published: (2024) -
Correction: Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.
by: Nessrin Alomran, et al.
Published: (2022)