Amantadine variant - aryl conjugates that inhibit multiple M2 mutant - amantadine resistant influenza a viruses

• Main Authors: Christina Tzitzoglaki (Author), Anja Hoffmann (Author), Andreea L. Turcu (Author), Patrick Schmerer (Author), Chunlong Ma (Author), George Laros (Author), Christos Liolios (Author), Brea José (Author), Jun Wang (Author), Santiago Vázquez (Author), Michaela Schmidtke (Author), Antonios Kolocouris (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Influenza A viruses can cause a serious future threat due to frequent mutations. Amantadine and rimantadine drugs inhibit influenza A M2 wild-type (WT; bearing in the protein M2 proton channel serine at position-31) viruses by binding and blocking M2 WT channel-mediated proton current. The resistant...