Corticosteroid-induced immunosuppression ultimately does not compromise the efficacy of antibiotherapy in murine Mycobacterium ulcerans infection.

• Main Authors: Teresa G Martins (Author), Gabriela Trigo (Author), Alexandra G Fraga (Author), José B Gama (Author), Adhemar Longatto-Filho (Author), Margarida Saraiva (Author), Manuel T Silva (Author), António G Castro (Author), Jorge Pedrosa (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Buruli ulcer (BU) is a necrotizing disease of the skin, subcutaneous tissue and bone caused by Mycobacterium ulcerans. It has been suggested that the immune response developed during the recommended rifampicin/streptomycin (RS) antibiotherapy is protective, contributing to bacterial clea...