Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation

• Main Authors: Anroop B. Nair (Author), Jigar Shah (Author), Shery Jacob (Author), Bandar E. Al-Dhubiab (Author), Vimal Patel (Author), Nagaraja Sreeharsha (Author), Pottathil Shinu (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of rizatriptan and assess the practicability of its development...