Increased coproporphyrin serum levels in healthy volunteers treated with the cholesterol uptake inhibitor ezetimibe

• Hauptverfasser: Jonny Kinzi (Verfasst von), Markus Grube (Verfasst von), Isabell Seibert (Verfasst von), Werner Siegmund (Verfasst von), Henriette E. Meyer zu Schwabedissen (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2024-10-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Ezetimibe undergoes glucuronidation that results in the active metabolite ezetimibe phenoxy‐glucuronide (ezetimibe‐glucuronide). This phase‐II metabolite was shown to interact with the clinically relevant hepatic transporter organic anion transporting polypeptide (OATP) 1B1. In recent years...