Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells

• Main Authors: Filip Bergqvist (Author), Elena Ossipova (Author), Helena Idborg (Author), Joan Raouf (Author), Antonio Checa (Author), Karin Englund (Author), Petter Englund (Author), Payam Emami Khoonsari (Author), Kim Kultima (Author), Craig E. Wheelock (Author), Karin Larsson (Author), Marina Korotkova (Author), Per-Johan Jakobsson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacological inhibition of microsomal prostaglandin E synthase (mPGES)-1 for selective reduction in prostaglandin E2 (PGE2) biosynthesis is protective in experimental models of cancer and inflammation. Targeting mPGES-1 is envisioned as a safer alternative to traditional non-steroidal anti-inflam...