Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice

• Главные авторы: Yongchuan Gu (Автор), Tony T.-A. Chang (Автор), Jingli Wang (Автор), Jagdish K. Jaiswal (Автор), David Edwards (Автор), Noel J. Downes (Автор), H. D. Sarath Liyanage (Автор), Courtney R. H. Lynch (Автор), Frederik B. Pruijn (Автор), Anthony J. R. Hickey (Автор), Michael P. Hay (Автор), William R. Wilson (Автор), Kevin O. Hicks (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Предметы: article
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3-(3-Morpholinopropyl)-7,8-dihydro-6H-indeno[5,6-e][1,2,4]triazine 1,4-dioxide (SN30- 000), an analog of the well-studied bioreductive prodrug tirapazamine (TPZ), has improved activity against hypoxic cells in tumor xenografts. However, little is known about its biotransformation in normal tissues....