HSV-1/TLR9-Mediated IFNβ and TNFα Induction Is Mal-Dependent in Macrophages

• Main Authors: Joanna Zyzak (Author), Małgorzata Mitkiewicz (Author), Ewa Leszczyńska (Author), Patryk Reniewicz (Author), Paul N. Moynagh (Author), Jakub Siednienko (Author)
• Format: Book
• Published: Karger Publishers, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Innate immune response is a universal mechanism against invading pathogens. Toll-like receptors (TLRs), being part of a first line of defense, are responsible for detecting a variety of microorganisms. Among them TLR9, which is localized in endosomes, acts as a sensor for unmethylated CpG motifs pre...