Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization

• Main Authors: Chloé Dias (Author), Nissrine Ballout (Author), Guillaume Morla (Author), Katia Alileche (Author), Christophe Santiago (Author), Ida Chiara Guerrera (Author), Adeline Chaubet (Author), Jerome Ausseil (Author), Stephanie Trudel (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background In mucopolysaccharidosis type III (MPS III, also known as Sanfilippo syndrome), a pediatric neurodegenerative disorder, accumulation of abnormal glycosaminoglycans (GAGs) induces severe neuroinflammation by triggering the microglial pro-inflammatory cytokines production via a TLR...