Extracellular vesicles from microglial cells activated by abnormal heparan sulfate oligosaccharides from Sanfilippo patients impair neuronal dendritic arborization

• Autori principali: Chloé Dias (Autore), Nissrine Ballout (Autore), Guillaume Morla (Autore), Katia Alileche (Autore), Christophe Santiago (Autore), Ida Chiara Guerrera (Autore), Adeline Chaubet (Autore), Jerome Ausseil (Autore), Stephanie Trudel (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2024-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background In mucopolysaccharidosis type III (MPS III, also known as Sanfilippo syndrome), a pediatric neurodegenerative disorder, accumulation of abnormal glycosaminoglycans (GAGs) induces severe neuroinflammation by triggering the microglial pro-inflammatory cytokines production via a TLR...