Adult and pediatric physiologically‐based biopharmaceutics modeling to explain lamotrigine immediate release absorption process

• Главные авторы: Edilainy Rizzieri Caleffi‐Marchesini (Автор), Amanda Antunes Herling (Автор), Julia Macente (Автор), Rodolfo Hernandes Bonan (Автор), Priscila deFreitas Lima (Автор), Rafaela Moreno (Автор), Veriano Alexandre (Автор), Nitin Bharat Charbe (Автор), Fernanda Belincanta Borghi‐Pangoni (Автор), Rodrigo Cristofoletti (Автор), Andréa Diniz (Автор)
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• Опубликовано: Wiley, 2024-02-01T00:00:00Z.
• Предметы: article
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Abstract Physiologically‐based biopharmaceutics modeling (PBBM) has potential to accelerate the development of new drug and formulations. An important application of PBBM is for special populations such as pediatrics that have pharmacokinetics dependent on the maturation process. Lamotrigine (LTG) i...