Tissue pharmacokinetics of antisense oligonucleotides

Tissue pharmacokinetics of antisense oligonucleotides

Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue. Quantitative understanding of tissue PK and RNA knockdown for various ASO chemistries, conjugations, and...

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Main Authors: Erica Bäckström (Author), Alessandro Bonetti (Author), Per Johnsson (Author), Stefan Öhlin (Author), Anders Dahlén (Author), Patrik Andersson (Author), Shalini Andersson (Author), Peter Gennemark (Author)
Format: Book
Published: Elsevier, 2024-03-01T00:00:00Z.
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