Tissue pharmacokinetics of antisense oligonucleotides

• Main Authors: Erica Bäckström (Author), Alessandro Bonetti (Author), Per Johnsson (Author), Stefan Öhlin (Author), Anders Dahlén (Author), Patrik Andersson (Author), Shalini Andersson (Author), Peter Gennemark (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue. Quantitative understanding of tissue PK and RNA knockdown for various ASO chemistries, conjugations, and...