Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency

• Main Authors: Shaoning Wang (Author), Chunxiu Liu (Author), Cunyang Wang (Author), Jia Ma (Author), Hui Xu (Author), Jianbo Guo (Author), Yihui Deng (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, arsenic trioxide (ATO) was encapsulated in liposomes via copper acetate (Cu(OAc)2) gradients and high entrapment efficiency of over 80% was obtained. The average particle size and the zeta-potential of the liposomes were detected to be 115.1 ± 29.1 nm and −21.97 ± 0.6 mV, respectively...