Evaluation of fasted and fed simulated intestinal fluid in predicting poorly soluble drugs using 9-point approach

• Main Authors: Rana Tamimi (Author), Ibrahim Khadra (Author), Hannah Batchelor (Author), Gavin Halbert (Author), Maria Ines Silva (Author)
• Format: Knjiga
• Izdano: University of Huddersfield Press, 2023-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The extent of absorption of orally administered drugs depends on their solubility in human intestinal fluid (HIF). Simulated intestinal fluid is used as biorelevant media to determine drug solubility in vitro. In this study, 9-point bioequivalent simulated intestinal media was used to assess the sol...