Trypanosoma cruzi disrupts thymic homeostasis by altering intrathymic and systemic stress-related endocrine circuitries.

• Autores principales: Ailin Lepletier (Autor), Vinicius Frias de Carvalho (Autor), Patricia Machado Rodrigues e Silva (Autor), Silvina Villar (Autor), Ana Rosa Pérez (Autor), Wilson Savino (Autor), Alexandre Morrot (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2013-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

We have previously shown that experimental infection caused by Trypanosoma cruzi is associated with changes in the hypothalamus-pituitary-adrenal axis. Increased glucocorticoid (GC) levels are believed to be protective against the effects of acute stress during infection but result in depletion of C...