Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes

• Main Authors: Min Gao (Author), Yanling Qiu (Author), Tianqi Cao (Author), Dungao Li (Author), Jingwen Wang (Author), Yiren Jiao (Author), Zhiyun Chen (Author), Junjiu Huang (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background High-temperature requirement protease A2 (HtrA2/Omi) is a mitochondrial chaperone that is highly conserved from bacteria to humans. It plays an important role in mitochondrial homeostasis and apoptosis. In this study, we investigated the role of HtrA2 in mouse oocyte maturation....