COE targets EphA2 to inhibit vasculogenic mimicry formation induced by hypoxia in hepatocellular carcinoma

• Main Authors: Jue Chen (Author), Shu-Ying Dai (Author), Su Wu (Author), Meng-Ke Wu (Author), Ke-Ke Yu (Author), Jun-Chi Liu (Author), Jia-Yu Chang (Author), Yan-Qing Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundVasculogenic Mimicry (VM) can reduce the efficacy of anti-angiogenesis and promote distant metastasis in hepatocellular carcinoma (HCC). Our previous studies have found that Celastrus orbiculatus extract (COE) can inhibit the VM formation in HCC by reducing EphA2 expression. However the un...