Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases

• Autores principales: Artur Świerczek (Autor), Krzysztof Pociecha (Autor), Hanna Plutecka (Autor), Marietta Ślusarczyk (Autor), Grażyna Chłoń-Rzepa (Autor), Elżbieta Wyska (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Current treatment strategies of autoimmune diseases (ADs) display a limited efficacy and cause numerous adverse effects. Phosphodiesterase (PDE)4 and PDE7 inhibitors have been studied recently as a potential treatment of a variety of ADs. In this study, a PK/PD disease progression modeling approach...