Discovery of an effective anti-inflammatory agent for inhibiting the activation of NF-κB

• Main Authors: Yaoyao Yan (Author), Qi Lv (Author), Feilong Zhou (Author), Yujie Jian (Author), Liu Xinhua (Author), Xing Chen (Author), Yong Hu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, based on the effect of compounds on the activation of NF-κB and NO release, compound 51 was discovered as the best one with NO release inhibition IC50 value was 3.1 ± 1.1 μM and NF-κB activity inhibition IC50 value was 172.2 ± 11.4 nM. Compound 51 could inhibit the activation of NF-κB...