Inhibition of P-Glycoprotein Asymmetrically Alters the In Vivo Exposure Profile of SGC003F: A Novel Guanylate Cyclase Stimulator

• Main Authors: Jinle Lou (Author), Nan Li (Author), Xue Jiang (Author), Xu Cai (Author), Lingchao Wang (Author), Xia Wu (Author), Wenpeng Zhang (Author), Chunmei Jin (Author), Xiaomei Zhuang (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a novel guanylate cyclase stimulator, SGC003F is being developed for the treatment of heart failure with a reduced ejection fraction (HFrEF). This study aimed to assess the effect of P-glycoprotein (P-gp) inhibition on SGC003F exposure in vivo, comparing plasma and tissue levels, and evaluating t...