Optimizations of In Vitro Mucus and Cell Culture Models to Better Predict In Vivo Gene Transfer in Pathological Lung Respiratory Airways: Cystic Fibrosis as an Example

• Main Authors: Rosy Ghanem (Author), Véronique Laurent (Author), Philippe Roquefort (Author), Tanguy Haute (Author), Sophie Ramel (Author), Tony Le Gall (Author), Thierry Aubry (Author), Tristan Montier (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The respiratory epithelium can be affected by many diseases that could be treated using aerosol gene therapy. Among these, cystic fibrosis (CF) is a lethal inherited disease characterized by airways complications, which determine the life expectancy and the effectiveness of aerosolized treatments. B...